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Serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals
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Abstract
Dear Editor, We write in response to correspondence from Whitaker et al. in this Journal (1). The authors demonstrate increases in seropositivity for SARS-CoV-2 antibodies against the spike protein as the roll out of COVID-19 vaccines continues, whilst parallel assessment of nucleocapsid antibodies remained stable. This study is an example of the use of parallel assessment of spike (S) and nucleocapsid (N) antibodies to discriminate between natural infection and vaccine related seropositivity (2) (3). This approach remains attractive, but as the pandemic rolls on it is worth considering the paucity of evidence about the impact of vaccination on antibody production in response to a subsequent natural infection
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Description
peer-reviewed
The full text of this article will not be available in ULIR until the embargo expires on the 05/08/2022
Publisher
Elsevier
Citation
Journal of Infection;83 (4), pp. e9-e10
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Funding Information
Sustainable Development Goals
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Type
Report
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/