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The components of variance and the critical difference in specific markers of bone turnover in healthy adult males and postmenopausal women.
Date
2002
Abstract
The study outlined here is part of an overall project, which aims to identify the optimum marker of bone resorption for both healthy young males and post-menopausal, non-osteoporotic women, and is as yet ongoing1. The purpose of this investigation was to quantify the components of variance in specific biochemical markers of bone turnover in healthy males and post-menopausal women i.e. total (CVS), analytical (CVA), within-subject biological (CVI) and betweensubject (CVG) variances. Using CVA and CVI for each individual, the individual critical difference (CDI) or least significant change (P<0.05) was calculated as previously described2. This value represents the minimal difference between two measurements of a biochemical marker that indicates a medically significant alteration of homeostasis (and is not due to normal biological and/or analytical variability alone). Given the CD of these markers the viability of using them in the assessment and/or monitoring of bone metabolism will be considered.
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Description
peer-reviewed
Publisher
National Institute of Health Sciences
Citation
National Institute of Health Sciences Research Bulletin;1 (4), pp.44-45
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Funding Information
Enterprise Ireland (EI)