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Targeting the tumor microenvironment: Potential strategy for cancer therapeutics

Date
2023
Abstract
Cellular and stromal components including tumor cells, immune cells, mesenchymal cells, cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment (TME). TME plays a crucial role in reprogramming tumor initiation, uncontrolled proliferation, invasion and metastasis as well as response to therapeutic modalities. In recent years targeting the TME has developed as a potential strategy for treatment of cancer because of its life-threatening functions in restricting tumor development and modulating responses to standard-of-care medicines. Cold atmospheric plasma, oncolytic viral therapy, bacterial therapy, nano-vaccine, and repurposed pharmaceuticals with combination therapy, antiangiogenic drugs, and immunotherapies are among the most effective therapies directed by TME that have either been clinically authorized or are currently being studied. This article discusses above-mentioned therapies in light of targeting TME. We also cover problems related to the TME-targeted therapies, as well as future insights and practical uses in this rapidly growing field.
Supervisor
Description
Publisher
Elsevier
Citation
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, 1869 (6), 166746
Collections
Physics
Bernal Institute
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Thorat_2023_Targeting.pdf
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Keywords
tumor microenvironment, tumor associated macrophage, immunotherapy, repurposed drugs, oncolytic virus
ULRR Identifiers
https://doi.org/10.34961/researchrepository-ul.23675154
 https://researchrepository.ul.ie/handle/10344/11841
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Funding Information
Sustainable Development Goals
(3) Good Health and Well-Being
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Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/4.0/
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