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Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome.
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Date
2015
Abstract
The natural history of NMDA receptor (NMDAR) antibody encephalitis in adults and children is altered by treatment with immunosuppressive therapy or tumor removal.1 In adult cohorts, early initiation of immunotherapy appears to be beneficial.1,2 In the largest series to date, Titulaer et al.1 demonstrated that earlier treatment was associated with a modified Rankin Scale (mRS) score of 2 or less in a cohort of 501 adults and children (univariate analysis p5 0.009, multivariable analysis p, 0.0001).Multivariable analysis on 177 children within the cohort showed that earlier treatment was associated with an mRS score of 2 or less, although this did not reach statistical significance (p 5 0.067).1 An mRS score of 2 indicates slight disability and that the patient is unable to carry out all previous activities.
Supervisor
Description
peer-reviewed
Publisher
American Academy of Neurology
Citation
Neurology (R) Neuroimmunology & Neuroinflammation;2 (4), e130
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ULRR Identifiers
Funding code
Funding Information
Sustainable Development Goals
External Link
Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/