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Wood-derived hydrogels as a platform for drug-release systems
Date
2021
Abstract
Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic and cross-linking behaviors of precursor solutions were tuned to produce highly porous hydrogel architectures via freeze-drying. Pore sizes in the range of 100–160 μm were obtained. Varying lignin molecular structure played a key role in tailoring swelling and mechanical performance of these gels with organosolv-type lignin showing optimum properties due to its propensity for intermolecular cross-linking, achieving a compressive modulus around 11 kPa. Paracetamol was selected as a standard drug for release tests and its release rate was improved with the presence of lignin (50% more compared to pure cellulose hydrogels). This was attributed to a reduction in molecular interactions between paracetamol and cellulose. These results highlight the potential for the valorization of lignin as a platform for drug-release systems.
Supervisor
Description
peer-reviewed
Publisher
American Chemical Society
Citation
ACS Sustainable Chemistry & Engineering;9 (6), pp. 2515-2522
Files
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Culebras_2021_Wood.pdf
Adobe PDF, 854.81 KB
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Funding Information
Horizon 2020, European Union (EU)