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In vitro analysis of a physiological strain sensor formulated from a PEDOT: PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite
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Date
2021
Abstract
Biodegradable strain sensors able to undergo controlled degradation following implantation have recently received significant interest as novel approaches to detect pathological tissue swelling or non-physiological stresses. In this study, the physicomechanical, electrochemical and active pressure sensing behavior of an electrically conductive and biodegradable poly(glycerol sebacate urethane) (PGSU) composite, reinforced with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) functionalized carbon nanotubes (CNTs), was evaluated in vitro. Analysis of these PGSU-CNTs composites demonstrated that the incorporation of functionalized CNTs into a biodegradable elastomer resulted in enhanced mechanical strength, conductivity and tailored matrix biodegradation. PGSU-CNT composites were subsequently formulated into flexible and active pressure sensors which demonstrated optimal sensitivity to applied 1% uniaxial tensile strains. Finally, cytocompatibility analysis a with primary neural culture confirmed that PGSU-CNT composites exhibited low cytotoxicity, and supported neuron adhesion, viability, and proliferation in vitro.
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peer-reviewed
Publisher
Elsevier
Citation
Materials Science and Engineering: C;121, 111857
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Guo_2021_In_Vitro.pdf
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Funding Information
Science Foundation Ireland (SFI), European Regional Development Fund (ERDF), European Union (EU)