Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

Ryan, Phelim; Motherway, Catherine; Powell, James; Elsaka, Ahmed; Ali Sheikh, Ambreen; Jahangir, Azhar; O'Connell, Nuala H.; Dunne, Colum P.

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Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

Ryan, Phelim; Motherway, Catherine; Powell, James; Elsaka, Ahmed; Ali Sheikh, Ambreen; Jahangir, Azhar; O'Connell, Nuala H.; Dunne, Colum P.

Date

2019

Abstract

The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata (N=21, 28%) was the next most prevalent species, and has been identified most frequently since 2012. C. glabrata was associated with a higher mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/mL). Notably, 37% of C. glabrata isolates were resistant to fluconazole, with 13% resistant to amphotericin B, highlighting the need for prudent antifungal stewardship to impede development of multi-drug-resistant C. glabrata in the ICU setting.

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peer-reviewed

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Elsevier

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Journal of Hospital Infection;102 (3), pp. 347-350

Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

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Sustainable Development Goals

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