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Formulating a stable mannitol infusion while maintaining hyperosmolarity

Date
2020
Abstract
Mannitol infusion is commonly used in the treatment of intracranial hypertension following traumatic brain injury. It has long been known to have stability issues, specifically, mannitol recrystallises from solutions greater than 10% w/v in ambient conditions. This can happen at any time, whether on the pharmacy shelf or during a medical procedure. This study describes the stability limits of 20% w/v mannitol infusion (the most common strength used clinically) and proposes a number of safer, stable and tuneable hyperosmotic formulations of mannitol in combination with clinically acceptable osmotic agents (NaCl, sorbitol and glycerol).
Supervisor
Description
peer-reviewed
Publisher
MDPI
Citation
Pharmaceutics;12 (2)
Collections
Bernal Institute
Synthesis and Solid State Pharmaceutical Centre
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Kavanagh_2020_Formulating.pdf
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Keywords
Intracranial hypertension, mannitol, mannitol instability, raised intracranial pressure, recrystallisation, reformulation, traumatic brain injury
ULRR Identifiers
https://hdl.handle.net/10344/8635
 https://doi.org/10.34961/14879
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Funding Information
Science Foundation Ireland (SFI), European Research Council (ERC)
Sustainable Development Goals
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