Date
2023
Abstract
Ovarian cancer (OC) is a common gynecological cancer worldwide. Unfortunately, the lack of early detection methods translates into a substantial cohort of women grappling with the pressing health crisis. The discovery of extracellular vesicles (EVs) (their major subpopulation exosomes, microvesicles, and apoptotic bodies) has provided new insights into the understanding of cancer. Exosomes, a subpopulation of EVs, play a crucial role in cellular communication and reflect the cellular status under both healthy and pathological conditions. Tumor-derived exosomes (TEXs) dynamically influence ovarian cancer progression by regulating uncontrolled cell growth, immune suppression, angiogenesis, metastasis, and the development of drug and therapeutic resistance. In the field of OC diagnostics, TEXs offer potential biomarkers in various body fluids. On the other hand, exosomes have also shown promising abilities to cure ovarian cancer. In this review, we address the interlink between exosomes and ovarian cancer and explore their theragnostic signature. Finally, we highlight future directions of exosome-based ovarian cancer research.
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Description
Publisher
American Chemical Society
Citation
ACS Omega, 2023
Collections
Physics
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Thorat_2023_Unlocking.pdf
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Keywords
ovarian cancer (OC), metastasis, exosomes, Physical sciences
ULRR Identifiers
https://doi.org/10.34961/researchrepository-ul.24231025
 https://researchrepository.ul.ie/handle/10344/12258
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Funding Information
Sustainable Development Goals
(3) Good Health and Well-Being
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Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/4.0/
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