Loading...
Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis
Date
2021
Abstract
Objective:To investigate the efficacy and safety of antidepressants for back and osteoarthritis pain compared with placebo. Design: Systematic review and meta-analysis. Data Sources: Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, International Pharmaceutical Abstracts, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform from inception to 15 November and updated on 12 May 2020. Eligibility Criteria For Study Selection: Randomised controlled trials comparing the efficacy or safety, or both of any antidepressant drug with placebo (active or inert) in participants with low back or neck pain, sciatica, or hip or knee osteoarthritis. Data Extraction and Synthesis: Two independent reviewers extracted data. Pain and disability were primary outcomes. Pain and disability scores were converted to a scale of 0 (no pain or disability) to 100 (worst pain or disability). A random effects model was used to calculate weighted mean differences and 95% confidence intervals. Safety (any adverse event, serious adverse events, and proportion of participants who withdrew from trials owing to adverse events) was a secondary outcome. Risk of bias was assessed with the Cochrane Collaboration’s tool and certainty of evidence with the grading of recommendations assessment, development and evaluation (GRADE) framework.
Supervisor
Description
peer-reviewed
Publisher
BMJ Publishing Group
Citation
BMJ Open;372, m4825
Collections
Files
Keywords
Funding code
Funding Information
Sustainable Development Goals
External Link
Type
Article
Rights
https://creativecommons.org/licenses/by-nc-sa/1.0/