Loading...
Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers
Date
2020
Abstract
The blood-brain barrier (BBB) has a significant contribution to homeostasis and protection of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the treatment of CNS disorders. To overcome this limitation, the use of nanocarriers for drug delivery across the BBB has recently been exploited. Nanocarriers can utilize different physiological mechanisms for drug delivery across the BBB and can be modified to achieve the desired kinetics and efficacy. Consequentially, several nanocarriers have been reported to act as functional nanomedicines in preclinical studies using animal models for human diseases. Given the rapid development of novel nanocarriers, this review provides a comprehensive insight into the most recent advancements made in nanocarrier-based drug delivery to the CNS, such as the development of multifunctional nanomedicines and theranostics.
Supervisor
Description
peer-reviewed
The full text of this article will not be available in ULIR until the embargo expires on the 09/01/02021
Publisher
Future Medicine
Citation
Nanomedicine;15 (2), pp. 205-214
Files
Loading...
manuscript_R1_JM.pdf
Adobe PDF, 2.74 MB