Date
2023
Abstract
Migraine, a neurovascular condition, is a chronic and lifelong disease that affects about 15% of the population worldwide. Although the exact pathophysiology and etiology of migraine are still unclear, oxidative stress, inflammation, and neuroendocrine imbalances are identified as the critical risk factors for migraine attacks. Curcumin is an active component and a polyphenolic diketone compound extracted from turmeric. Curcumin is a promising candidate for preventing and controlling migraine due to its anti‑inflammatory, antioxidative, anti-protein aggregate, and analgesic effects. In the present review, we have evaluated experimental and clinical studies investigating the impact of liposomal curcumin and nano-curcumin on the frequency and severity of migraine attacks in patients. Although the results are promising, more studies should be conducted in this area to show the exact efficacies of curcumin on clinical symptoms of migraine and investigate its potential mechanisms.
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Description
Publisher
Elsevier
Citation
Biomedicine & Pharmacotherapy 164, 114910
Collections
Biological Sciences
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Barreto_2023_Impact.pdf
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Keywords
curcumin, migraine, oxidative stress, inflammation, Biological sciences
ULRR Identifiers
https://doi.org/10.34961/researchrepository-ul.23566014
 https://hdl.handle.net/10344/11728
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Funding Information
Isfahan University of Medical Sciences with grant number 2400263 and ethical code IR.MUI. RESEARCH.REC.1400.486
Sustainable Development Goals
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