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Publication Open Access Impact of web accessibility on cognitive engagement in individuals without disabilities: Evidence from a psychophysiological study(Public Library of Science, 2025-07-30)Web accessibility features on websites are designed for individuals with disabilities that include low vision and cognitive impairments, but such features can benefit everyone. This study investigates the impact of accessibility features of the web on ambient/focal visual attention and cognitive processing in individuals without disabilities. The study involved 20 participants reading news websites with different levels of low vision and cognitive-related accessibility features while their eye movements and heart rate variability were monitored. The findings show that cognitive engagement declined over time when no accessibility enhancements were present. The study also demonstrates that enhancing cognitive accessibility leads to increased user cognitive engagement, while low vision accessibility features make websites easier to read. These findings are corroborated by self-reports and psychophysiological measures, such as eye-tracking metrics and heart rate variability. The effects from these psychophysiological measures, together with participants’ self-reports, support the benefits of enhancing web accessibility features for all users. The implications for future website design are also discussed.Publication Open Access A fitted finite element method for singularly perturbed elliptic problems with characteristic boundary layers(Elsevier, 2026-03-01)A Petrov–Galerkin finite element method on a rectangular Shishkin mesh is constructed for a singularly perturbed elliptic problem in two space dimensions. The solution contains a regular boundary layer and two characteristic boundary layers. The test functions are taken to be a tensor product of exponential splines in one coordinate direction and hat functions in the other direction, which results in a stable higher (than first) order numerical method. The differential equation contains a zero order term. Compared to the case of no zero order term, the character of the exponential splines are more complicated and the associated pointwise error analysis relies more on the finite element formulation. Error bounds are given in a global pointwise norm. Numerical results are presented to illustrate the performance of the method.Publication Open Access Valorisation of digestate: Characteristics, products, processes and potential(Elsevier, 2025-11-01)Anaerobic digestion (AD) plays a critical role in meeting renewable energy needs and managing solid and liquid waste streams, thereby making significant contributions towards sustainability and the circular economy. However, AD generates a large amount of digestate as a by-product. Digestate contains undigested organic fractions, micro and macro-nutrients, inorganic materials, trace metals etc. It is essential to develop appropriate ways for managing and valorising digestate for truly harnessing the potential of AD. This review critically analyses the current state of the art on valorisation and management of digestate. It starts with a review of key digestate characteristics that have a great impact on the valorisation potential and products. Different valorisation pathways based on the analysis of digestate properties are then reviewed. The interaction among characteristics of digestate, valorisation technologies, potential products and economic challenges is critically reviewed and discussed. Furthermore, the separation technologies, advanced valorisation processes and their potential are discussed. Techno-economic aspects are briefly discussed. Some comments on policies and regulations are included. Key conclusions on the state of the art, specific suggestions for further research, and some comments on the outlook are included at the end. The review will be useful to researchers, technologists, and policymakers interested in sustainability and the circular economy.Publication Open Access Publication Open Access Influence of additives on antisolvent crystallization of carbamazepine dihydrate(American Chemical Society, 2025-08-04)Carbamazepine, an antiepileptic drug, crystallizes in its usually observed needlelike dihydrate form (CBZ-DH) via antisolvent crystallization. In this work, we have investigated the influence of additives on the shapes and sizes of CBZ-DH crystals produced from ethanolic solution using water as an antisolvent. The influence of four relevant polymeric additives-polyethyleneglycol (PEG), sodium dodecyl sulfate (SDS), hydroxypropyl methylcellulose (HPMC), and Poloxamer 407-at different loadings was initially investigated on the vial scale. HPMC was found to have the most significant impact on -CBZ-DH crystals, leading to block-like particles in the vials, while the needlelike morphology persisted in the presence of the other additives. HPMC was selected for further investigations using continuous antisolvent crystallizers. The experiments were performed using HPMC as an additive with two types of crystallizers: a stirred tank crystallizer (CSTC) and a crystallizer comprising a fluidic oscillator (FO) and helical coil (HC). While the X-ray powder diffraction (XRPD) of the lab-scale crystalline product does not differ from the XRPD at the vial scale, implying the dominance of the same crystal face during growth, kite-shaped crystals of CBZ-DH were formed in the continuous crystallizer. Comparison of the length and width distributions of these crystals and the steady-state yield of CBZ-DH with the crystals produced in the absence of additives suggested retarded kinetics under the impact of additives. The coefficient of the growth rate estimated using population balance models was lower in the presence of HPMC. The kite-shaped crystals of CBZ-DH reported in this work will provide an impetus for experimental and modeling-based studies of the impact of additives on the shape of crystals, which can be taken advantage of for enhanced dissolution profiles.
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