University of Limerick Research Repository

Recent Submissions

  • PublicationOpen Access
    Therapeutic role of probiotics in motor and non-motor symptoms of Parkinson’s disease
    (Open Exploration Publishing, 2025-12-15) Páez-García, Salomón; Hernández-Triana, Daniel; Esparza-Salazar, Felipe; Barreto, George E.; Rodriguez-Oroz, Maria Cruz; Borda, Miguel Germán
    Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor symptoms, in which gut microbiota alterations have emerged as a potential pathogenic factor, causing disruption of the brain-gut-microbiota (BGM) axis. Recent evidence supports the role of BGM axis disruption in enhancing neuroinflammation, alpha-synuclein (α-syn) aggregation, and dopaminergic neurodegeneration. Emerging therapeutic strategies targeting dysbiosis, such as probiotics and fecal microbiota transplantation (FMT), have become a new focus of investigation for PD treatment. Proposed mechanisms include modulation of immune responses, enhancement of intestinal barrier integrity, production of neuroactive metabolites such as short-chain fatty acids, and reduction of oxidative stress. This narrative review summarizes current evidence on probiotics as a therapeutic strategy in PD. By analyzing data from randomized controlled trials and preclinical studies, we highlight the beneficial effects of probiotics in improving motor and non-motor symptoms of PD, including constipation, depression, and anxiety. Strains such as Lactobacillus plantarum PS128 and Bifidobacterium animalis Probio-M8 show particular promise. Although probiotics have demonstrated a favorable safety profile and potential as an adjunctive therapy for PD, future research should focus on standardized protocols, biomarker identification, and exploration of combined microbiota-targeted strategies.
  • PublicationOpen Access
    Pedagogies of practice in english language teacher education: student teachers’ experiences and preferences
    (EUROKD, 2025-12-01) Farr, Fiona; Karlsen, Petter Hagen
    This paper discusses the ways in which (English) language teachers are supported in their preparation for professional practice during their teacher education programmes. Using the framework of pedagogies of practice (representations, decompositions and approximations) (Grossman et al. 2009), it surveys 26 student teachers in relation to their experiences of the practice-oriented components of their teacher education programmes to discern their experiences, practices and perceptions. It specifically explores the context of Ireland and Norway. These opportunities to engage in practice, whether individually or collectively, assessed or unassessed, are discussed in terms of their potential for meaningful reflective practice (Dewey 1933). The results suggest that these students have opportunities to engage in a wide array of pedagogies of practice during their teacher education programmes, both individually and collectively. Many of these are assessed but others are formative in nature. Both groups of students place very high value on these practice-engagement elements of their programmes, with this value and preference increasing the closer these activities move towards real classroom practice, which is the most highly prized of all. Implications and suggestions are included in the concluding remarks.
  • PublicationOpen Access
    The Antagonistic influence of phytic acid on zinc absorption: an in vitro comparison of inorganic and chelated trace mineral sources
    (MDPI, 2026-01-01) Rock, Niamh; Clynes, Martin; Horgan, Karina; Murphy, Richard; O'Sullivan, Finbarr; Keenan, Joanne
    Background/Objectives: Zinc, an important trace metal, requires daily intake but dietary antagonists including phytic acid reduce its absorption. It is unclear if phytic acid affects zinc absorption at the level of bioaccessibility (how much soluble zinc is available from digestion) or bioavailability (how much zinc is absorbed by the intestine). This study investigates at which level this occurs at and if the zinc source alters the response. Methods: Following a standardised in vitro digestion (INFOGEST), the yield of soluble zinc was measured as the bioaccessible fraction from inorganic and chelated zinc sources, with and without phytic acid. Bioavailability was assessed by measuring cellular zinc uptake in intestinal cell lines (Caco-2 and IPEC-J2). Results: Phytic acid affected the bioaccessibility of zinc, with varying impacts depending on the zinc source. Zinc proteinate had the highest bioaccessibility (42%) without phytic acid, while inorganic zinc sulphate (24%) and zinc bisglycinate (27%) were lower. ZnSO4 was more susceptible to phytic acid antagonism than chelated zinc sources (from 2:100 molar ratio of phytic acid: zinc), while the chelated zinc sources were only affected at a molar ratio of 4:100, with zinc bisglycinate being more susceptible than zinc proteinate. Cellular zinc uptake (bioavailability) and toxicity at equimolar concentrations were unaffected by phytic acid. Conclusions: This study found that phytic acid affected bioaccessibility, not bioavailability. The zinc source impacts the response. Zinc proteinate was consistently more bioaccessible while both chelated zinc sources were less susceptible to phytic acid than inorganic zinc.
  • PublicationOpen Access
    Development of nanocomposite bioactive diffusion films (BDFs) combined with gamma irradiation for control of the rice weevil sitophilus oryzae , a stored product pest
    (Wiley Periodicals LLC, 2026-01-01) Begum, Tofa; Follett, Peter A.; Salmieri, Stephane; Jaiswal, Lily; Lacroix, Monique
    The fumigant toxicity of 6 essential oils (EOs) (Mediterranean, Southern, citrus, cinnamon, Asian, and savory thyme), 2 citrus extracts (CEs: organic OCE and natural NCE), and 2 active formulations (microfluidized nanoemulsions AF-1 and AF-2) was investigated for control of rice weevil ( Sitophilus oryzae ), a stored product pest. In bioassays, AF-1 and AF-2 at 0.6 μL/mL exhibited higher insecticidal efficacy compared to single EOs and CEs after 72 h of exposure. AF-2 showed higher acetylcholinesterase enzyme inhibition in rice weevils than AF-1. Oil-in-water nanoemulsions (NEs) of AF-1 and AF-2 were prepared by microfluidization, resulting in a decrease in droplet size (DS) from 232 to 116 nm and 230 to 40 nm, and an increase in encapsulation efficiency (EE) from 30% to 77% and from 11% to 79% respectively. To exploit the insecticidal attributes of these NEs, 6 nanocomposite bioactive diffusion films (BDFs) were prepared based on chitosan (CH), poly(butylene adipate-co-terephthalate (PBAT), or polylactic acid (PLA), all reinforced with cellulose nanocrystals (CNC), and containing either AF-1 or AF-2. Films were evaluated as diffusion devices in bags of rice infested with weevils. CH films induced the highest insect mortality (78%–83%) after 14 days, compared to 6% in controls. Gamma irradiation at 200 Gy alone caused 62% mortality, which increased to 82%100% after combination with the BDFs after 14 days. The presence of CNC in BDFs reduced the % release of bioactive NEs by 12%–27% compared to the films without CNC.
  • PublicationOpen Access
    You are not alone – third-party punishment by individuals and groups empowers victims
    (Sage, 2026-01-01) Hechler, Stefanie; Posten, Ann-Christin
    Third-party punishment communicates with offenders to resocialize them. However, little is known about what it communicates to victims. Considering group contexts, the current research focuses on the effects on victims of either one individual or the entire group punishing offenders. Five preregistered experiments (N = 1,231; student and online adult samples from Germany and the United Kingdom) demonstrate that various forms of third-party punishment empower victims (Studies 1, 3, 4, and 5) and that this effect is amplified when the entire group supports the punishment (Studies 1–4). Sequential mediation analyses and experimental designs show that punishment restores value consensus, which in turn revalidates victims’ group membership status, thereby empowering victims. Regardless of explicit messages, standalone punishment empowers victims (Studies 4 and 5). These findings emphasize the communicative effects of third-party punishment on victims, contributing to our understanding of how punishment can support them in coping.