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Publication Open Access Influence of sire fertility on the metabolism of in vitro produced embryos(Bioscientifica Ltd., 2026-07-01)Bull field fertility varies greatly and is largely influenced by differences in early embryo survival rather than fertilization failure alone. We, therefore, investigated whether sire fertility status is reflected in the metabolomic profile of embryo-conditioned culture media. Six Holstein-Friesian bulls were selected from a population of 840 sires and classified using an adjusted sire fertility index. Mean (±SD) values were 4.27 ± 0.61% for highly fertile bulls (HF, n = 3) and 13.1 ± 1.85% for sub-fertile bulls (SF, n = 3). Cumulus–oocyte complexes were fertilized using frozen–thawed semen from individual bulls. On day 7 post-fertilization, grade 1 blastocysts (pools of n = 15 per bull; n = 3 replicates) were transferred to fresh culture medium for 24 h. On day 8, embryo-conditioned media from both fertility treatments and unconditioned media were collected, snap-frozen, and subjected to high-throughput untargeted metabolomic profiling. A total of 149 metabolites were detected. Unsupervised analysis revealed substantial overlap between HF and SF sire-derived embryo-conditioned media, while both differed from unconditioned media. The relative abundance of 30 metabolites was altered by embryo presence, irrespective of sire fertility. Direct comparison of HF vs SF sire-derived embryo-conditioned media identified only three differentially abundant metabolites. However, multivariate machine learning analysis identified a panel of eight N-acetylated amino acids, which discriminated embryos derived using semen from bulls of divergent fertility status with high accuracy (AUROC = 0.903). In conclusion, sire fertility status imparts a subtle but detectable metabolic imprint on the early embryo, which can be exploited to non-invasively discriminate embryos according to potential developmental competence.Publication Open Access The dynamics of meaning in life and their associations with burnout within- and between persons(Sage, 2026)Meaning in Life has been a suggested contributor to burnout, both in prevention and acceleration. Meaning in Life is comprised of presence (having meaning) and search (seeking meaning), and these two facets may operate independently of each other. This study explores the relationship between meaning in life, measured by the Meaning in Life Questionnaire, and burnout, measured by the Bergen Burnout Inventory, across time. Longitudinal data from an initial cohort of 1239 frontline workers (baseline) in the UK and Ireland were collected from March 2020 to May 2023 to examine within- and between-person differences in presence and search, their interaction, and their relationship to burnout and its dimensions. The findings demonstrate that presence and search for meaning operate differently in relation to burnout. Interactive effects were found: for overall burnout and cynicism, search for meaning was associated with poorer outcomes especially among those with low presence of meaning.Publication Open Access Exploring experiences of the enactment of creativity in lower second level education in Ireland: the framework for Junior Cycle(Springer Nature, 2026-07-09)Internationally, many education systems have attempted to embed creativity into schools, often with limited impact. Changes to lower second level schooling in Ireland, The Framework for Junior Cycle, aimed to integrate creativity as a core principle underpinning the Framework, and as a Key Skill. Drawing on data from student surveys (n = 3612), student focus groups (n = 219), interviews with teachers (n = 136), principals (n = 24) and parents (n = 60) from two visits to 12 case study schools, this paper explores participants experiences of creativity within the revised Junior Cycle and considers what supported and hindered the enactment of creativity at this stage of schooling. Following thematic analysis of qualitative data, and statistical analysis of quantitative data, the findings indicate that teachers and principals indicate a focus on creativity increased since the introduction of the Framework. Teachers stated they were engaging in more creative approaches to teaching and learning, which was supported by parents' views. However, students were less positive regarding their experiences of creativity. Students communicated that they experienced creativity when they had opportunities to make choices on their learning, were exposed to different resources and could present their work in a variety of ways. Overall, the student data paints a picture of limited creativity within Junior Cycle. Assessment acted as both a support and a hindrance to creativity. All participants indicated that project-based learning, in the form of Classroom Based Assessments, provided opportunities for creativity. Summative assessment was a significant hindrance to enacting creativity. The paper concludes by considering how creativity can be more effectively enacted within Junior CyclePublication Open Access Lightweight real-time detectors of apple-leaf diseases operating on embedded devices(Public Library of Science, 2026-07-09)Agricultural leaf disease detection is crucial for early intervention and yield protection in precision agriculture. Among representative economic crops, such as apples, leaf lesions are typically small and appear in complex backgrounds, making accurate detection performed on resource-constrained embedded devices challenging. To address this, we propose a lightweight small-object detection models, namely the dynamic Differential Compensation Lightweight-YOLO (DCL-YOLO) model and its pruned version (DCL-YOLO-P), based on YOLO11n. A novel Dual-Aspect Feature Complementary Mapping (DAFCM) module type is embedded in their backbone to recover lost semantic and spatial information, while the original YOLO11n’s neck is replaced by an Efficient Enhanced Cross-Scale Feature Fusion (EE-CSFF) module, which incorporates Gated Differential Convolutional Fusion (GDCF) modules to strengthen cross-scale information flow and small-object representation. Experimental results obtained on the ALDSOD dataset show that, compared with the YOLO11n baseline, DCL-YOLO improves recall from 81.9% to 84.6%, mAP50 from 86.8% to 88.4%, and mAP50:95 from 47.0% to 47.8%, while also reducing the parameter count from 2.58 M to 1.91 M and Giga Floating-Point Operations (GFLOPs) from 6.3 to 5.5. After applying Layer-Adaptive Magnitude-based Pruning (LAMP), the parameter count and GFLOPs are further reduced to 0.75 M and 2.7, respectively, with mAP50 and mAP50:95 still exceeding the baseline by 1.2 and 0.5 percentage points, respectively. When deployed on an embedded device, the pruned model achieved 15.2 FPS and 139 msec per image, confirming its applicability in real-time scenarios. Furthermore, cross-domain validation, performed on the Global Wheat Head Detection (GWHD) dataset, indicates the stable generalization capabilities of the proposed models across environmental domain shifts. The DCL-YOLO’s source code is publicly available at: https://github.com/q123-code/dcl-yolo.Publication Open Access Polydextrose as a sugar replacement in pound cake production: impact on water activity, colour, texture, and consumer acceptability(Oxford Academic, 2026-06-15)Nutritionists have highlighted the need to minimise the consumption of sugar to safeguard health. Polydextrose (PDX) is a food additive that is regarded as soluble fibre and appears to be promising when considering development of confectionery foods. In this study, the impact of incorporating PDX as a replacement of sugar in pound cake was investigated. Polydextrose was substituted at 20%, 40%, and 60% level to replace sugar in pound cake and compared to control (100% sugar with no PDX). Subsequently, the physicochemical properties such as moisture and water activity, colour, texture profile, and sensory properties were assessed.The moisture values ranged from 19.97±0.22% to 23.51±1.04%. The highest value was observed in supplemented cake (60% PDX) with value of 23.51±1.04%. No statistically significant difference exists in water activity of the cake containing 20%, 40%, and 60% PDX (p>.05). Colour and texture parameters were influenced by the addition of PDX in the pound cake. Sensory property was analysed on a 9-point hedonic scale by 25 panellists. The overall impression (acceptability) values from 6.4±1.3 to 7.2±1.0. The most preferred by panellist was pound cake containing 20% PDX. The implication of this is that 20% PDX can be possibly incorporated into cake productions as a partial replacement to refined sugar in confectionery industries. Overall, the addition of PDX as a partial replacement of sugar may be considered for use in confectionery product
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