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Publication Open Access Editorial: Remedying the injured brain in cognitive impairment: potential neuroimmune communication signaling and therapeutic opportunities(Frontiers Media SA, 2025-09-30)Nearly 16% of the global population suffers from neurological disorders linked to acute or chronic inflammation, including neurodegenerative and cerebral neuroimmune diseases (1, 2). Neuroimmune dysregulation is widely acknowledged as a pivotalmechanism in the pathogenesisof these disorders, involving intricate immune responses and cellular interactions within the central nervous system (CNS) (3). Recent advances at the intersection of neuroscience and immunology have greatly enhanced our understanding of neuroimmune signaling pathways (4). Studies have shown that resident immune cells in the brain, such as microglia and astrocytes, together with peripheral immune cells, including T cells, B cells, and monocytes, play critical roles in neuroinflammation, vascular injury, and cognitive decline (5–7). For instance, the functional states of microglia, such as the pro-inflammatory M1-type and neuroprotective M2-type polarization, as well as their transformation into disease-associated microglia, coupled with aberrant activation of the complement system, are significantly implicated in the progression of neurodegenerative diseases (8). Furthermore, the infiltration of peripheral immune cells and their communication with the CNS remain major themes in neuroimmune research (9, 10). This Research Topic brings together cutting-edge advances in neuroimmune signaling, novel microglial polarization states, peripheral immune system-to-CNS immune crosstalk, and multi-omics biomarkers associated with cognitive impairment and dementia, with a special focus on innovative therapeutic strategies targeting neuroimmune inflammation. The Research Topic includes six papers: four original research papers, one systematic review, and one opinion piece.Publication Open Access Radio frequency interference, its mitigation and its implications for the civil aviation industry(MDPI, 2025-06-18)Radio Frequency Interference has emerged as a growing challenge for aviation safety and system integrity due to the increasing spectral overlap between communication technologies and aviation systems. This paper investigates the sources, types, and consequences of RFI in Global Navigation Satellite Systems, Instrument Landing Systems, and altimeters used in civil aviation. A detailed examination of both intentional and unintentional interference is presented, highlighting real-world incidents and simulated impact models. The study analyzes technical mechanisms such as receiver desensitization, intermodulation, and cross-modulation, and further explores UAV-based interference detection frameworks. Mitigation strategies are reviewed, including regulatory practices, spectrum filters, shielding architectures, and dynamic UAV sensing systems. Comparative insights into simulation results, shielding techniques, and regulatory gaps are discussed. The paper concludes with recommendations for enhancing current aviation standards and suggests a hybrid validation model combining in-flight measurements with simulation-based assessments. This research contributes to the understanding of electromagnetic vulnerabilities in aviation and provides a basis for future mitigation protocols.Publication Open Access Health impacts of electronic nicotine delivery systems: an umbrella review of systematic reviews(BMJ, 2025-10-10)Background The rise of electronic nicotine delivery systems (ENDS) has introduced new challenges to tobacco control and regulation, particularly among young adults, raising questions about their safety. This umbrella review aimed to synthesise existing systematic reviews with or without meta-analyses to evaluate the health impacts of ENDS Methods We conducted a systematic literature search via the PICO strategy across multiple databases, focusing on e-cigarettes, ENDS and e-liquids, while excluding non-nicotine e-cigarette and nicotine replacement therapies (NRTs). Health outcomes include a range of clinical diseases and physiological changes. Quality assessment was performed via assessing the methodoligcal quality of systematic reviews 2 (AMSTAR-2), and the findings were synthesised narratively and in tables, prioritising the highest-rated reviews. The meta-analyses used R software (V.4.3) random effects models, and evidence quality was assessed via the Grading of Recommendations, Assessment, Development and Evaluation criteria. Results Of the 5055 records, 69 systematic reviews were included. Systematic reviews have indicated increased risks of cardiovascular and respiratory diseases, mental health issues and substance abuse with ENDS use especially among adolescents. Cardiovascular risk factors included increased heart rate (mean difference (MD) 1.41, 95% CI 0.81 to 2.01, I2=91%) from 25 studies; increased blood pressure (MD for systolic blood pressure=0.51 mm Hg, 95% CI 0.26 to 0.75, I2=89%; MD for diastolic blood pressure=0.59 mm Hg, 95% CI 0.35 to 0.83, I2=82%) from 23 studies; endothelial dysfunction and increased platelet activity. Respiratory risk factors included reduced lung function and a higher incidence of asthma in nine studies (OR 1.30, 95% CI 1.1 to 1.55; I2=43%) and chronic obstructive pulmonary disease. Mental health concerns, such as depression and suicidality, were also prevalent among adolescent ENDS users. Nine studies reported a negative effect of ENDS on periodontal health. Evidence of carcinogens has been found in the urinary examinations of ENDS users in some studies. The adverse events reported in seven randomised controlled trials with 2611 participants were similar between ENDS and NRT (RR 1.13, 95% CI 0.83 to 1.54, I2=12%). Conclusions Exposure to ENDS is harmful to various organ systems, especially cardiovascular and respiratory systems. Comprehensive regulatory measures and public health strategies are necessary to curb the use of ENDS, particularly among young people.Publication Open Access From glia limitans to glial scars: in vitro coculture studies of the astrocyte and meningeal interaction(BMC, 2025-10-21)The brain-meninges interface, comprising of astrocytes and meningeal cells seperated by a shared basement membrane, plays critical roles in the central nervous system. Recent work has shown the importance of signalling between the brain and the meninges in neurodevelopment, health, disease, and in stem cell migration. Despite this recent research, the brain-meninges interface is significantly understudied. This systematic review evaluates 27 studies which examine astrocyte-meningeal cell co-culture models. The papers were identified from a search of PubMed, Scopus, and Web of Science and screened for eligibility according to the PRISMA guidelines. These papers utilized the astrocyte-meningeal cell co-culture to mimic different biological interfaces within the central nervous system such as the spinal cord, optic nerve, and the brain-meninges interface to examine various outcomes such as neurite outgrowth, morphology, glial scar formation, and protein expression. Our findings highlight significant gaps in our understanding of the brain-meninges interface, along with inconsistencies in methodologies when establishing the astrocyte-meningeal cell co-culture model. Finally, this review recommends a standardisation of methodologies for astrocyte-meningeal cell co-culture including model validation and detailed protocols. This will allow for improved understanding of these important interfaces in the brain.Publication Open Access Early intervention matters: a national retrospective analysis of pre-EMS defibrillation and community response in out-of-hospital cardiac arrest in Ireland from 2021–2023(BMJ, 2025-10-15)Out-of-Hospital Cardiac Arrest (OHCA) represents a major cause of mortality in Ireland. With low survival rates and the time-sensitive nature of cardiac arrest, early intervention is paramount in optimizing patient outcomes. As such, early community-based response, through bystander CPR and automated external defibrillator (AED), remains a fundamental component in Ireland’s chain of survival. However, significant gaps exist in recent research examining the relationship between community-based interventions and patient survival in the Irish healthcare context.
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