Cummins_2011_biological.pdf (803.01 kB)
Biological evaluation of nano hydroxyapatite zirconia (HA-ZrO2) composites for load bearing applications.
journal contributionposted on 2023-01-10, 12:43 authored by Ian Brook, Christine Freeman, Sarah Grubb, Niamh CumminsNiamh Cummins, Declan Curran, Colin Reidy, STUART HAMPSHIRESTUART HAMPSHIRE, M.R. Towler
The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatitezirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings and novel microwave sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favourable response from rat osteosarcoma cells (ROS). In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be a due to the incorporation of Sr and the formation of a surface apatite layer.
PublicationJournal of Biomaterials Applications;27(3), pp. 291-298
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