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Concurrent vaccination against equine influenza and equine herpesvirus - a practical approach

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posted on 2017-08-24, 15:10 authored by Sarah Gildea, Maria Jose Sanchez Higgins, Gillian P. Johnson, Cathal Dominic Walsh, Ann Cullinane
Background There is a lack of information concerning concurrent administration of vaccines against equine influenza virus (EIV) and equine herpesvirus 1 and 4 (EHV-1/4).Objectives The primary objective of this study was to determine the impact of the concurrent use of EIV and EHV-1/4 vaccines in Thoroughbred racehorses on their humoral immune response to EIV.Methods This study was carried out on a population of 30 horses using an inactivated whole-virus EIV vaccine and an inactivated EHV-1/4 vaccine. Horses were randomly allocated to vaccination group A or B. Horses in group A were vaccinated against EIV and EHV-1/4 2 weeks apart. Horses in group B were vaccinated against EIV and EHV-1/4 on the same day. Whole-blood samples were collected on the day of vaccination and 2 weeks and 6 weeks postvaccination. Antibody levels against EIV and EHV-1/4 were measured using the single radial haemolysis and serum neutralisation test, respectively.Results The pattern of EIV antibody response post-vaccination was similar for both groups. Highest EIV antibody levels were recorded 2 weeks post-vaccination, and a significant decrease in antibody level was observed 4 weeks later. Horses in group B demonstrated a significantly higher EIV antibody response postvaccination. Overall, there was no significant difference in EHV-1/4 antibody response between the two groups post-vaccination.Conclusion In this study, concurrent vaccination against EIV and EHV-1/4 increased the response to EIV and did not compromise the humoral immune response to EHV-1/4.

History

Publication

Influenza and Other Respiratory Viruses;10 (5), pp. 433-437

Publisher

Wiley Open Access

Note

peer-reviewed

Other Funding information

Department of Agriculture, Food and the Marine

Language

English

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