Exosome-based smart drug delivery tool for cancer theranostics
Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.
Funding
Plasmonic Nanomedicine Coupled Biomolecular Fingerprinting of Brain Cancer
Science Foundation Ireland
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Publication
ACS Biomaterials Science and Engineering, 2023, 9, (2), pp. 577–594Publisher
American Chemical SocietyAlso affiliated with
- Bernal Institute
Sustainable development goals
- (3) Good Health and Well-being
External identifier
Department or School
- Physics