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Thorat_2022_Exosome.pdf (5.96 MB)

Exosome-based smart drug delivery tool for cancer theranostics

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journal contribution
posted on 2023-07-12, 11:40 authored by Rishav Kar, Rajib Dhar, Sayantanee Mukherjee,, Sagnik Nag, Sukhamoy Gorai, Nobendu Mukerjee, Dattatreya Mukherjee, Rishabh Vatsa, Mamtha Chandrakanth Jadhav, Arabinda Ghosh, Arikketh Devi, Anand Krishnan, Nanasaheb ThoratNanasaheb Thorat

 Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.


Plasmonic Nanomedicine Coupled Biomolecular Fingerprinting of Brain Cancer

Science Foundation Ireland

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ACS Biomaterials Science and Engineering, 2023, 9, (2), pp. 577–594


American Chemical Society

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