Improvement in dietary inflammatory index score after 6-month dietary intervention is associated with reduction in interleukin-6 in patients with coronary heart disease: The AUSMED heart trial
Version 2 2023-05-26, 15:10Version 2 2023-05-26, 15:10
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journal contribution
posted on 2023-05-26, 15:10authored byHannah L. Mayr, Catherine Itsiopoulos, Audrey TierneyAudrey Tierney, Miguel Ruiz-Canela, James R. Hebert, Nitin Shivappa, Colleen J. Thomas
The Dietary Inflammatory Index (DII) was designed to measure the inflammatory potential
of one's diet. Evidence from observational studies supports that a higher (ie, more proinflammatory)
DII score is associated with inflammation and cardiometabolic diseases. We
hypothesized that reduction in DII score would improve inflammatory cytokines. To test
this hypothesis, we assessed data from a dietary intervention trial in patients with
diagnosed coronary heart disease (CHD) to determine whether reduction in DII scores
through healthy diets is linked to improvement in inflammatory and related cardiometabolic
risk markers. Participants (n = 65, 83% male) were randomized to a Mediterranean
diet or low-fat diet intervention for 6-months. Anthropometry, body composition and blood
markers were measured and DII scores were calculated from 7-day food diaries. After 6-
months, in participants who completed the intervention (n = 56), reduction in DII score
correlated significantly with reduction in high sensitivity interleukin-6 (hs-IL-6) (r = 0.34,
95% CI 0.05, 0.56) and triglycerides (r = −0.30, 95% CI -0.51, −0.06) but not with C-reactive protein, adiponectin, glucose, body composition or anthropometry. The adjusted mean
difference in hs-IL-6 and triglycerides between the highest and lowest tertiles of DII
improvement was −0.47 pg/mL (95% CI 0.41, 1.10) and +0.30 mmol/L (95% CI 1.06, 1.59),
respectively. The present study found that improvement in DII score through healthy diet
intervention was linked with reduced levels of hs-IL-6, but also increased triglycerides, in
adult Australian patients with CHD. Future research is warranted to investigate the impact
of change in DII on cardiometabolic risk markers in larger cohorts, other disease
populations or healthy subjects and with longer-term follow up.
History
Publication
Nutrition Research;55, pp. 108-121
Publisher
Elsevier
Note
peer-reviewed
Other Funding information
La Trobe University, United States National Institute for Diabetes
Rights
This is the author’s version of a work that was accepted for publication in Nutrition Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nutrition Research, 2018, 55, pp. 108-121, https://doi.org/10.1016/j.nutres.2018.04.007