University of Limerick
Browse
Guo_2021_In_Vitro.pdf (2.46 MB)

In vitro analysis of a physiological strain sensor formulated from a PEDOT: PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite

Download (2.46 MB)
journal contribution
posted on 2021-02-15, 11:43 authored by Ghazal Tadayyon, Katarzyna Krukiewicz, James Britton, Aitor Larrañaga, Catalina Vallejo-Giraldo, Marc Fernandez-Yague, Yina Guo, Gemma Orpella-Aceret, Lu Li, Anup Poudel, Manus J. Biggs
Biodegradable strain sensors able to undergo controlled degradation following implantation have recently received significant interest as novel approaches to detect pathological tissue swelling or non-physiological stresses. In this study, the physicomechanical, electrochemical and active pressure sensing behavior of an electrically conductive and biodegradable poly(glycerol sebacate urethane) (PGSU) composite, reinforced with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) functionalized carbon nanotubes (CNTs), was evaluated in vitro. Analysis of these PGSU-CNTs composites demonstrated that the incorporation of functionalized CNTs into a biodegradable elastomer resulted in enhanced mechanical strength, conductivity and tailored matrix biodegradation. PGSU-CNT composites were subsequently formulated into flexible and active pressure sensors which demonstrated optimal sensitivity to applied 1% uniaxial tensile strains. Finally, cytocompatibility analysis a with primary neural culture confirmed that PGSU-CNT composites exhibited low cytotoxicity, and supported neuron adhesion, viability, and proliferation in vitro.

Funding

The Hasse-Witt Matrix of an Algebraic Curve

National Science Foundation

Find out more...

History

Publication

Materials Science and Engineering: C;121, 111857

Publisher

Elsevier

Note

peer-reviewed

Other Funding information

SFI, ERDF, European Union (EU)

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC