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In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds

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posted on 2018-12-13, 12:01 authored by Eleni Sioriki, Ronan Lordan, Fady Nahra, Kristof Van Hecke, IOANNIS ZABETAKISIOANNIS ZABETAKIS, Steven P. Nolan
The anti‐atherogenic (anti‐inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N‐heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet‐activating factor (PAF)‐induced platelet aggregation was probed. All complexes were found to possess anti‐aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti‐inflammatory drugs.

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Publication

ChemMedChem;13 (23), pp. 2484-2487

Publisher

Wiley and Sons Ltd

Note

peer-reviewed

Other Funding information

King Abdullah University of Science and Technology(KAUST)

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This is the peer reviewed version of the following article :ChemMedChem 2018 13 (23), pp. 2484-2487 In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds Sioriki, Eleni, Lordan, Ronan, Nahra, Fady, Van Hecke, Kristof, Zabetakis, Ioannis, Nolan, Steven P. which has been published in final form at;https://doi.org/10.1002/cmdc.201800601 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms

Language

English

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