University of Limerick
Browse

MRI guided magneto-chemotherapy with high-magnetic-moment iron oxide nanoparticles for cancer theranostics

Download (1.54 MB)
journal contribution
posted on 2020-04-30, 10:50 authored by Ashwini Salunkhe, Vishwajeet Khot, S. I. Patil, Syed A.M. Tofail, Joanna Bauer, Nanasaheb D. Thorat
Elevating and monitoring the temperature of tumors using magnetic nanoparticles (MNPs) still presents a challenge in magnetic hyperthermia therapy. The efficient heating of tumor volume can be achieved by preparing MNPs with high magnetization values. The next-generation approach to magnetic resonance image (MRI)-guided magneto-chemotherapy of cancer based on high-magnetic-moment iron oxide nanoparticles is proposed. The proof of concept is validated by cellular MRI experiments on breast cancer cells. To explore magneto-chemotherapy, we developed high-magnetic-moment iron oxide (Fe3O4) nanoparticles (NPs) using base diisopropylamine (DIPA), which plays a dual role as reducing agent and surface stabilizer. Spherical NPs with ∼12 nm size and a high magnetization value of about 92 emu g–1 at room temperature are obtained by this unique method. A high specific absorption rate value of ∼717 wg–1 was obtained for Fe3O4 NPs in water at an alternating magnetic field of 20 kAm–1 and frequency of 267 kHz, which is attributed to the high magnetization value. The magneto-polymeric micelle structure is formed by using Pluronic F127, and anticancer drug doxorubicin is conjugated in the micelle by electrostatic interactions for magneto-chemotherapy. Finally, the magnetic resonance imaging (MRI)-guided magneto-chemotherapy was achieved on breast cancer (MCF7) cells with an overall ∼96% killing of cancer cells attained in 30 min of magneto-chmeotherapy.

Funding

Study on Aerodynamic Characteristics Control of Slender Body Using Active Flow Control Technique

Japan Society for the Promotion of Science

Find out more...

Using the Cloud to Streamline the Development of Mobile Phone Apps

Innovate UK

Find out more...

History

Publication

ACS Applied Bio Materials;3 (4), pp. 2305-2313

Publisher

American Chemical Society

Note

peer-reviewed

Other Funding information

ERC, IRC

Rights

© 2020 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials , copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.0c00077

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC