posted on 2020-07-31, 10:26authored byDavy Vancampfort, Brendon Stubbs, Elvira Lara, Mathieu Vandenbulcke, Nathalie Swinnen, Lee Smith, Joseph Firth, Matthew P. Herring, Mats Hallgren, Ai Koyanagi
Background
Sedentary behavior (SB) is associated with poor cognitive performance. However, the contribution of sedentary time to risk of mild cognitive impairment (MCI) remains unclear. This study assessed the association of SB with MCI in six low- and middle-income countries.
Methods
The Study on Global Ageing and Adult Health (SAGE) survey included 34,129 adults aged ≥50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. SB was self-reported and expressed as a categorical variable [<8 or ≥8 h per day (high SB)]. The definition of MCI was based on the recommendations of the National Institute on Ageing-Alzheimer's Association. Multivariable logistic regression analysis was conducted to assess the association between SB and MCI.
Results
The overall prevalence (95%CI) of MCI and high SB (i.e., ≥8 h/day) were 15.3% (14.4%–16.3%) and 10.1% (9.0%–11.3%), respectively. After adjustment for potential confounders, being sedentary for ≥8 h/day was associated with a 1.56 (95%CI = 1.27–1.91) times higher odds for MCI. A one-hour increase in SB was associated with a 1.08 (95%CI = 1.05–1.11) times higher odds for MCI.
Conclusion
Our study results highlight the need to further explore a sedentary lifestyle as a potential risk factor for MCI or subsequent dementia. Longitudinal and intervention studies are warranted to confirm/refute the current findings.
History
Publication
Experimental Gerontology;108, pp.174-180
Publisher
Elsevier
Note
peer-reviewed
Other Funding information
National Institute for Health Research (NIHR)
Rights
This is the author’s version of a work that was accepted for publication in Experimental Gerontology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Experimental Gerontology, 2018, 108, pp. 174-180, https://doi.org/10.1016/j.exger.2018.04.017