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OptiCogs: feasibility of a multicomponent intervention to rehabilitate people with cognitive impairment post-stroke

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posted on 2023-10-26, 07:58 authored by Mairead O'DonoghueMairead O'Donoghue, Pauline BolandPauline Boland, Sinead Taylor, Edel Hennessy, Eva Murphy, siobhan leahy, John McManusJohn McManus, Dominika Lisiecka, HELEN PURTILLHELEN PURTILL, Rose GalvinRose Galvin, SARA HAYESSARA HAYES

Background Stroke is a leading cause of death and disability worldwide. Despite the prevalence and associated burden of cognitive impairment post-stroke, there is uncertainty regarding optimal cognitive rehabilitation for people post-stroke. This study aimed to assess whether a multicomponent intervention, called OptiCogs, is feasible, acceptable, and safe for people with cognitive impairment post-stroke. A secondary aim was to explore changes in cognitive function, fatigue, quality of life, physical function, and occupational performance, from pre-intervention to post-intervention. Methods A feasibility study was conducted where people post-stroke with cognitive impairment enrolled in a 6-week multicomponent intervention. The primary outcomes recorded included response rate, recruitment rate, retention rate, adherence to the intervention protocol, adverse events, and acceptability of the intervention to people post-stroke. Secondary outcomes included (i) change in cognitive functioning using the Addenbrooke’s Cognitive Examination III, (ii) fatigue using the Fatigue Severity scale, (iii) quality of life using the Stroke Specific Quality of Life scale (iv) physical function using the patient-reported outcomes measurement information system, and (v) patient-reported occupational performance using the Canadian Occupational Performance Measure. The Consolidated Standards of Reporting Trials extension reporting guidelines were followed, for pilot and feasibility studies, to standardize the conduct and reporting of this study. Results The response rate was 10.9%. Nine eligible participants were enrolled during the 4-month recruitment period, with eight participants completing the entire 6-week intervention, as well as the pre- and post-intervention outcome measures. There were no reported adverse events. Participants were satisfed with the intervention and found it acceptable overall. Results of the secondary outcomes were promising for cognitive function (ACE III, pre: 63.3±23.9 to post: 69±24.6), fatigue (FSS, pre: 52.5±7.3 to post: 45.6±7.2), quality of life (SSQoL, pre: 131.0±26.3 to post: 169.9±15.3), physical function (PROMIS-PF, pre: 15.5±6.3 to post: 15.8±5.3), and occupational performance (COPM performance, pre: 9.3±2.3 to post: 22.9±4.2) and COPM satisfaction, pre: 9.9±2.1 to post: 22.7±3.5). Conclusion Preliminary results suggest low-modest recruitment and high retention rates for the OptiCogs intervention. Changes in cognitive function, fatigue, quality of life, and self-reported occupational performance show improvement from pre- to post-intervention. These potential benefts require further testing in a larger pilot trial.

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Publication

Pilot and Feasibility Studies 9, 178

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BMC

Other Funding information

School of Allied Health, University of Limerick.

Also affiliated with

  • Health Research Institute (HRI)

Sustainable development goals

  • (3) Good Health and Well-being

Department or School

  • Allied Health
  • Mathematics & Statistics

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