University of Limerick
Browse
ODonnell_2021_Piezoelectricity.pdf (1.44 MB)

Piezoelectricity of the transmembrane protein ba3 cytochrome c oxidase

Download (1.44 MB)
journal contribution
posted on 2021-05-31, 10:24 authored by Joseph O'Donnell, Pierre-André Cazade, Sarah Guerin, Ahmed Djeghader, Ehtsham Ul Haq, Kai Tao, Ehud Gazit, Eiichi Fukada, Christophe Silien, Tewfik SoulimaneTewfik Soulimane, DAMIEN THOMPSONDAMIEN THOMPSON, Syed A.M. Tofail
Controlling the electromechanical response of piezoelectric biological structures including tissues, peptides, and amino acids provides new applications for biocompatible, sustainable materials in electronics and medicine. Here, the piezoelectric effect is revealed in another class of biological materials, with robust longitudinal and shear piezoelectricity measured in single crystals of the transmembrane protein ba3 cytochrome c oxidase from Thermus thermophilus. The experimental findings from piezoresponse force microscopy are substantiated using a range of control measurements and molecular models. The observed longitudinal and shear piezoelectric responses of ≈2 and 8 pm V−1 respectively, are comparable to or exceed the performance of commonly used inorganic piezoelectric materials including quartz, aluminum nitride, and zinc oxide. This suggests that transmembrane proteins may provide, in addition to physiological energy transduction, technologically useful piezoelectric material derived entirely from nature. Membrane proteins could extend the range of rationally designed biopiezoelectric materials far beyond the minimalistic peptide motifs currently used in miniaturized energy harvesters, and the finding of robust piezoelectric response in a transmembrane protein also raises fundamental questions regarding the molecular evolution, activation, and role of regulatory proteins in the cellular nanomachinery, indicating that piezoelectricity might be important for fundamental physiological processes

Funding

Mechanism of Cytokinesis in Animal Cells

National Science Foundation

Find out more...

Using the Cloud to Streamline the Development of Mobile Phone Apps

Innovate UK

Find out more...

History

Publication

Advanced Functional Materials;2100884

Publisher

Wiley

Note

peer-reviewed

Other Funding information

IReL Consortium, IRC, SFI

Language

English

Usage metrics

    University of Limerick

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC