Rasmuson_2018_Promotion.pdf (1.1 MB)
Promotion of mefenamic acid nucleation by a surfactant additive, docusate sodium
journal contribution
posted on 2019-02-08, 09:49 authored by Katalin Bodnár, Sarah P. Hudson, Åke C. RasmusonThe influence of docusate sodium (DOSS) on the nucleation of mefenamic acid (MEF) has been studied in different dimethylacetamide (DMA)–water mixtures. A series of induction time experiments were conducted under moderate supersaturations, varying the solvent composition and the concentration of DOSS. In 40% DMA–60% water, the presence of 0.1 and 0.2 mg/mL DOSS increased the nucleation rate. Evaluating the results by the classical nucleation theory reveals that the pre-exponential factor (A) increases by approximately 50% while the interfacial energy is essentially uninfluenced. It is also found that the crystal growth rate becomes higher in the presence of DOSS. It is thus hypothesized that transport and desolvation of MEF molecules are facilitated in the presence of DOSS. With increasing amount of DMA in the binary solvent mixture, the influence of DOSS appears to decrease.
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Crystal Growth and Design;19 (2), pp. 591-603Publisher
American Chemical SocietyNote
peer-reviewedOther Funding information
SFI, Irish Government’s Programme for Research in Third Level Institutions Cycle 5Rights
© Year ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work seehttp://dx.doi.org/10.1021/acs.cgd.8b00995Language
EnglishExternal identifier
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