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RACK1, a multifaceted scaffolding protein: structure and function.

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journal contribution
posted on 2016-02-12, 09:53 authored by David R. Adams, Dorit Ron, Patrick A. Kiely
The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β subunit of G-proteins (Gβ). RACK1 adopts a seven-bladed β-propeller structure which facilitates protein binding. RACK1 has a significant role to play in shuttling proteins around the cell, anchoring proteins at particular locations and in stabilising protein activity. It interacts with the ribosomal machinery, with several cell surface receptors and with proteins in the nucleus. As a result, RACK1 is a key mediator of various pathways and contributes to numerous aspects of cellular function. Here, we discuss RACK1 gene and structure and its role in specific signaling pathways, and address how posttranslational modifications facilitate subcellular location and translocation of RACK1. This review condenses several recent studies suggesting a role for RACK1 in physiological processes such as development, cell migration, central nervous system (CN) function and circadian rhythm as well as reviewing the role of RACK1 in disease.

Funding

Development of a structure identification methodology for nonlinear dynamic systems

National Research Foundation

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History

Publication

Cell Communication and Signaling;9:22

Publisher

BioMed Central

Note

peer-reviewed

Other Funding information

HRB, Irish Cancer Society

Language

English

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