Sarowar_2020_Rho.pdf (1.38 MB)
Rho GTPases in the amygdala—A switch for fears?
journal contributionposted on 2022-10-03, 10:39 authored by Tasnuva Sarowar, Andreas GrabruckerAndreas Grabrucker
Fear is a fundamental evolutionary process for survival. However, excess or irrational fear hampers normal activity and leads to phobia. The amygdala is the primary brain region associated with fear learning and conditioning. There,Rho GTPases are molecular switches that actas signaling molecules for further downstream processes that modulate, among others, dendritic spine morphogenesis and thereby play a role in fear conditioning. The three main Rho GTPases—RhoA, Rac1, and Cdc42, together with their modulators, are known to be involved in many psychiatric disorders that aﬀect the amygdala0s fear conditioning mechanism. Rich2, a RhoGAP mainly for Rac1 and Cdc42, has been studied extensively in such regard. Here, we will discuss these eﬀectors, along with Rich2, as a molecular switch for fears, especially in the amygdala. Understanding the role of Rho GTPases in fear controlling could be beneﬁcial for the development of therapeutic strategies targeting conditions with abnormal fear/anxiety-like behaviors.
Also affiliated with
- Bernal Institute
- Health Research Institute (HRI)
Department or School
- Biological Sciences