Solution mediated phase transformations between co-crystals

A solution mediated transformation between two co-crystal phases has been observed for the p-5 toluensulfonamide/triphenylphosphine oxide co-crystal system. This system has two known co-crystals with 1:1 and 3:2 stoichiometry respectively, and the ternary phase diagram (TPD) for the system has been determined in acetonitrile previously. By manipulating the solution composition in this 10 solvent to a region of the TPD where the 1:1 co-crystal is stable, the 3:2 co-crystal could be observed to convert to the 1:1 co-crystal. The corresponding transformation was true for the 1:1 co-crystal in a region of the TPD where the 3:2 co-crystal is stable; the 1:1 co-crystal converted to the 3:2 co-15 crystal.