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The mechanical responses of advecting cells in confined flow

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journal contribution
posted on 2023-01-10, 13:00 authored by Sinéad Á. Connolly, David NewportDavid Newport, Kieran Denis McGourty
Fluid dynamics have long influenced cells in suspension. Red blood cells and white blood cells are advected through biological microchannels in both the cardiovascular and lymphatic systems and, as a result, are subject to a wide variety of complex fluidic forces as they pass through. In vivo, microfluidic forces influence different biological processes such as the spreading of infection, cancer metastasis, and cell viability, highlighting the importance of fluid dynamics in the blood and lymphatic vessels. This suggests that in vitro devices carrying cell suspensions may influence the viability and functionality of cells. Lab-on-a-chip, flow cytometry, and cell therapies involve cell suspensions flowing through microchannels of approximately 100–800 μm. This review begins by examining the current fundamental theories and techniques behind the fluidic forces and inertial focusing acting on cells in suspension, before exploring studies that have investigated how these fluidic forces affect the reactions of suspended cells. In light of these studies’ findings, both in vivo and in vitro fluidic cell microenvironments shall also be discussed before concluding with recommendations for the field

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History

Publication

Biomicrofluidics;14, 031501

Publisher

American Institute of Physics

Note

peer-reviewed

Other Funding information

IRC

Language

English

Also affiliated with

  • Bernal Institute
  • Health Research Institute (HRI)

Department or School

  • School of Engineering

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