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Thermodynamics of risperidone and solubility in pure organic solvents

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posted on 2016-10-25, 15:04 authored by Donal Mealey, Michael Svärd, Åke C. Rasmuson
The solid-liquid solubility of the thermodynamically stable form I of the drug risperidone has been determined by a gravimetric method in nine pure organic solvents in the temperature range 278.15-323.15 K. The melting temperature and associated enthalpy of fusion of risperidone form I has been determined by differential scanning calorimetry (DSC) to be 442.38 K and 43.94 kJ mol(-1), respectively. The heat capacity of the solid form I and the melt have been determined over a range of temperatures by temperature-modulated DSC, and extrapolated data has been used to calculate the Gibbs energy, enthalpy and entropy of fusion from ambient temperature up to the melting point. The ideal solubility within a Raoult's law framework is obtained from the Gibbs energy of fusion, and the solution activity coefficient at equilibrium in the nine solvents quantified. Solutions in all solvents exhibit positive deviation from Raoult's law, with the highest solubility (closest to ideality) in toluene, an aprotic apolar solvent. The solubility curves plotted in a van't Hoff graph show non-linear behaviour and are well-approximated by a second order polynomial. (C) 2014 Elsevier B.V. All rights reserved.

Funding

PHILIP KAARET / UNIVERSITY OF IOWA FOSSIL JETS FROM BLACK HOLE TRANSIENTS RECENT XMM-NEWTON OBSERVATIONS HAVE LED TO THE DISCOVERY OF A LARGE SCALE X-RAY JET FROM THE LONG-TERM X-RAY TRANSIENT AND BLACK HOLE CANDIDATE 4U 175533. WE OBTAINED A FOLLOW-UP OB

National Aeronautics and Space Administration

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History

Publication

Fluid Phase Equilibria;375, pp. 73-79

Publisher

Elsevier

Note

peer-reviewed

Other Funding information

SFI, Swedish Research Council

Rights

This is the author’s version of a work that was accepted for publication in Fluid Phase Equilibria. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Fluid Phase Equilibria, 375, pp. 73-79, http://dx.doi.org/10.1016/j.fluid.2014.04.028

Language

English

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