posted on 2019-01-03, 16:58authored byDonna Clarke, I. Gorman, F. Ringholz, M. McDermott, D.W. Cox, Paul Greally, Barry Linnane, Paul McNally
Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in
school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool
children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children
with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to
be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.