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Serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals

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posted on 2022-10-14, 11:37 authored by Niamh Allen, Melissa Brady, Antonio Isidro Carrion Martin, Lisa Domegan, CATHAL WALSHCATHAL WALSH, Lorraine Doherty, Una Ni Riain, Colm Bergin, Catherine Fleming, Niall Conlon
Dear Editor, We write in response to correspondence from Whitaker et al. in this Journal (1). The authors demonstrate increases in seropositivity for SARS-CoV-2 antibodies against the spike protein as the roll out of COVID-19 vaccines continues, whilst parallel assessment of nucleocapsid antibodies remained stable. This study is an example of the use of parallel assessment of spike (S) and nucleocapsid (N) antibodies to discriminate between natural infection and vaccine related seropositivity (2) (3). This approach remains attractive, but as the pandemic rolls on it is worth considering the paucity of evidence about the impact of vaccination on antibody production in response to a subsequent natural infection



Journal of Infection;83 (4), pp. e9-e10




peer-reviewed The full text of this article will not be available in ULIR until the embargo expires on the 05/08/2022


This is the author’s version of a work that was accepted for publication in Journal of Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published inJournal of Infection Volume 83, Issue 4, October 2021, Pages e9-e10 ,



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